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Continue to ChatThat the primary effect of gene mutation may be as simple as the substitution of a single amino acid by another and may lead to profound secondary changes in protein structure and properties has recently been strongly indicated by the work of Ingram on hemoglobin. - Edward Lawrie Tatum from https://whatsmyquote.com/quote/that-the-primary-effect-of-gene-mutation-may-be-as-simple-as-the-substitution-of-a-single-amino-acid-by