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Continue to Chat8-4-2020; 10.1001/jamaoto.2020.0832 By: Eliezer, et al. Aim Report a covid-19 case with complete olfactory loss Keys Complete olfactory loss without nasal obstruction should alert clinician to suspect covid-19 Summary: SARS-CoV-2 infects human respiratory epithelial cells. Clinical features mainly include lower respiratory tract infection (fever, dry cough, dyspnea). Higher respiratory tract symptoms are more rare. However; 40 year old woman presents with acute loss of olfactory function without nasal obstruction. No dysgeusia. Few days before presentation: dry cough, myalgia en cephalalgia. No fever or rhinorrhea. Normal oto- and rhinoscopy. CT-scan and MRI-scan of nasal cavity showed bilateral inflammatory obstruction of olfactory clefts. Olfactory bulbs and tracts were normal. Since husband of patient had covid-19 the patient underwent pCR which rendered positive results. The origin of nasal cleft obstruction remains unknown but has been reported in patients following severe nasopharyngeal infection. However; no nasal obstruction in this patient. Coronaviruses could invade the brain via the cribriform plate close to the olfactory bulb and the olfactory epithelium. Complete olfactory loss without nasal obstruction should alert clinician to suspect covid-19 https://heelkunde.nl/nieuws/nieuwsbericht?newsitemid=31948829